Table 1.

S. Typhi mutants constructed for this study

DOI: http://dx.doi.org/10.7554/eLife.01229.003

S. Typhi strain	Genotype	Minimum inhibitory concentrations (μg/ml)
		Nalidixic acid	Norfloxacin	Ofloxacin	Ciprofloxacin	Gatifloxacin	Levofloxacin
Parent BRD948	ΔaroA, ΔaroC, ΔhtrA	1.5	0.064	0.047	0.008	0.008	0.012
DPT001	SNP in ΔaroC (codon 10)	1.5	0.064	0.047	0.008	0.008	0.012
S83Y	SNP in gyrA (codon 83)	256	0.5	0.25	0.125	0.125	0.125
S83F	SNP in gyrA (codon 83)	256	0.75	0.38	0.125	0.125	0.125
D87A	SNP in gyrA (codon 87)	48	0.75	0.19	0.094	0.064	0.064
D87N	SNP in gyrA (codon 87)	48	0.75	0.25	0.125	0.125	0.125
D87G	SNP in gyrA (codon 87)	48	0.75	0.25	0.125	0.125	0.25
S80I	SNP in parC (codon 80)	3	0.19	0.047	0.016	0.016	0.016
D87G-S80I	SNP in gyrA (codon 87) and SNP in parC (codon 80)	256	1	0.25	0.125	0.094	0.094
S83F-D87G	2 SNPs in gyrA (codons 83 and 87)	256	1	0.38	0.19	0.25	0.25
S83F-D87A	2 SNPs in gyrA (codons 83 and 87)	192	1.5	0.38	0.25	0.38	0.25
S83F-D87N	2 SNPs in gyrA (codons 83 and 87)	64	0.75	0.38	0.19	0.19	0.19
S83F-D87G-S80I	2 SNP in gyrA (codons 83 & 87) and SNP in parC (codon 80)	256	24	16	8	2	3