Table 2. European Society of Cardiology Definition of Advanced HF.
| • NYHA Class III-IV Symptoms |
| • Episodes of volume overload and/or peripheral hypoperfusion |
| • Objective evidence
of severe cardiac
dysfunction (EF<30%, Doppler Pseudonormal or Restrictive filling pattern, PCWP>16mmHg or RAP >12 mmHg) |
| • Severely impaired
functional capacity (Inability to exercise, 6MWD<300m, Peak VO2<12-14 ml/kg/min) |
| • HF
Hospitalizations (≥1 in past 6 months) |
| • Above occurring despite attempts to optimize diuretics, RAAS antagonists, BB, CRT or in the setting of intolerance to OMT |
Abbreviations: NYHA, New York Heart Association; LV, left ventricular; EF, ejection fraction; PCWP, pulmonary capillary wedge pressure; RAP, right atrial pressure; 6MWD, 6 minute walk distance; VO2 oxygen consumption; RAAS, renin-angiotensin-aldosterone system, BB, beta blockers, CRT, cardiac resynchronization therapy, OMT, optimal medical therapy