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. 2013 Dec 4;8(12):e82528. doi: 10.1371/journal.pone.0082528

Figure 3. Vaccine-induced FV-neutralizing antibody responses.

Figure 3

CB6F1 mice were prime- and boost-immunized with Ad5 and Ad5F35 based vectors of Ad.pIXgp70 combined with interleukin-encoding vectors as indicated. Total neutralizing antibody titers (A) and neutralizing IgG antibody titers (B) were analyzed 10 days after FV challenge infection. Statistically significant differences (P < 0.05; Kruskal-Wallis one-way analysis of variance on ranks with Dunns multiple comparison procedure) compared to unvaccinated mice (#) or mice immunized with Ad.pIXgp70 alone (*) are indicated. For statistical analysis, mice with viral loads below the detection limits were assigned the value 2. Values were subjected to statistical analysis without logarithmic transformation. Each dot represents an individual mouse, horizontal lines indicate median values. The dashed lines indicate the detection limit. Data are results of two independent experiments with similar outcome.