Table 1. Summary of immunization experiments.
| unvaccinated | Ad.pIXgp70 + Ad.empty | Ad.pIXgp70 + Ad.IL4 | Ad.pIXgp70 + Ad.IL5 | Ad.pIXgp70 + Ad.IL6 | Ad.pIXgp70 + Ad.IL7 | Ad.pIXgp70 + Ad.IL23 | |
|---|---|---|---|---|---|---|---|
| spleen weight 21 dpc (gram; mean ± SE) | 3,66 ± 0,28 | 2,20 ± 0,46 | 2,05 ± 0,42 | 0,96 ± 0,39 | 0,91 ± 0,38 | 2,47 ± 0,50 | 0,76 ± 0,37 |
| viral load in plasma 10 dpc (FFU / ml; median) | 9,99×104 | 6,35×104 | 2,97×103 | nd | nd | 3,80×103 | nd |
| viral load in spleen 21 dpc (SFFU / spleen; median) | 1,50×107 | 1,21×106 | 3,25×104 | 1,47×103 | nd | 4,68×104 | 3,61×102 |
| FV-specific CD4+ T cells 3 dpc (% MHC II Tet+ / CD4+; mean ± SE) | 0,04 ± 0,01 | 0,18 ± 0,03 | 0,14 ± 0,02 | 0,18 ± 0,04 | 0,21 ± 0,02 | 0,14 ± 0,03 | 0,20 ± 0,04 |
| neutralizing antibody titer 10 dpc (median) | 4 | 8 | 8 | 64 | 24 | 16 | 48 |
| neutralizing IgG antibody titer 10 dpc (median) | nd | nd | 5,15 | 104 | 128 | 20 | 48 |
abbreviations: dpc, days post challenge; nd, not detectable