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Development of antinociceptive tolerance to chronic ACHC-EM2 given at 20 μg/2 μL twice daily for the indicated time periods. Rats were tested in the tail-flick assay 5 min (a, white columns) and 15 min (b, striped columns) after injection. Mean ± S.E.M.; n = 7. Significance was determined by ANOVA; * labels P < 0.05 compared to the first day.
