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. 2013 Oct;136(10):2979–2991. doi: 10.1093/brain/awt222

Figure 2.

Figure 2

Semantic variant PPA (svPPA) shows distributed reductions in intrinsic connectivity and local functional brain activity. Group difference maps (semantic variant PPA < HC3) from ATL-seeded intrinsic connectivity (A) and fractional ALFF (fALFF, B) analyses were generated with a joint height-extent threshold (P < 0.01 for peak height and P < 0.05 for spatial extent). The overlap between the intrinsic connectivity network (ICN) and fractional ALFF group-difference maps is shown in C with two statistical thresholds chosen to illustrate the convergence of the findings [P < 0.05 (light blue) or P < 0.01 (dark blue) for peak height, and P < 0.05 for spatial extent]. Overlap maps are also visualized on a rendered brain surface using mri3dX (http://www.cubric.cf.ac.uk/Documentation/mri3dX/), where atrophied regions from the semantic variant PPA < HC3 voxel-based morphometry analysis (Supplementary Fig. 2) are highlighted in yellow. Amy = amygdala; Calc = calcarine; dPI = dorsal posterior insula; FI = frontoinsula; Fus = fusiform; Hes = Heschl's; lOcG = lateral occipital gyrus; MTG = middle temporal gyrus; PCC = posterior cingulate cortex; PCu = precuneus; PHG = parahippocampus; PoCG = postcentral gyrus; PrCG = precentral gyrus; rmPFC = rostral medial prefrontal cortex; STG = superior temporal gyrus.