Table 1.
Demographics and clinical assessments
| HC1 |
HC3 |
Semantic variant PPA |
HC3 – svPPA | ||||
|---|---|---|---|---|---|---|---|
| Mean (SD) | n | Mean (SD) | n | Mean (SD) | n | P-value | |
| Age, years | 66.2 (6.3) | 27 | 63.6 (5.8) | 17 | 63.4 (6.1) | 17 | 0.915 |
| Gender (M:F) | 15:12 | 9:8 | 9:8 | – | |||
| Education, years | 17.2 (1.8) | 27 | 17.1 (1.8) | 17 | 16.9 (2.6) | 17 | 0.817 |
| CDR total | 0.0 (0.0) | 27 | 0.0 (0.0) | 17 | 0.7 (0.4) | 17 | <0.001 |
| CDR, sum of boxes | 0.0 (0.0) | 27 | 0.0 (0.1) | 17 | 4.1 (2.8) | 17 | <0.001 |
| MMSE (max 30) | 29.4 (0.7) | 27 | 29.6 (0.7) | 17 | 26.4 (2.3) | 17 | <0.001 |
| BNT (max 15) | 14.5 (0.8) | 27 | 14.5 (0.7) | 17 | 6.1 (4.1) | 17 | <0.001 |
| PPVT (max 16) | 15.7 (0.7) | 23 | 15.8 (0.5) | 16 | 8.2 (4.4) | 16 | <0.001 |
| TASIT (max 14) | 11.7 (1.6) | 14 | 12.0 (0.8) | 4 | 6.8 (2.6) | 17 | <0.001 |
| Lexical fluency (D-words per minute) | 17.2 (3.3) | 22 | 17.3 (3.4) | 11 | 6.9 (3.3) | 17 | <0.001 |
| Category fluency (animals per minute) | 24.1 (5.4) | 27 | 23.3 (5.1) | 17 | 8.2 (3.8) | 17 | <0.001 |
| Modified trails (correct lines/min) | 24.2 (9.9) | 27 | 23.9 (7.9) | 17 | 47.1 (26.7) | 15 | 0.005 |
| Digit span (forward) | 7.7 (1.0) | 15 | 7.4 (1.1) | 15 | 6.6 (1.4) | 15 | 0.089 |
| Digit span (backward) | 6.0 (1.0) | 27 | 5.3 (1.4) | 16 | 4.9 (1.0) | 16 | 0.323 |
| Calculations (max 5) | 4.9 (0.4) | 27 | 4.7 (0.5) | 17 | 4.6 (0.5) | 16 | 0.636 |
| Syntax (max 5) | 4.9 (0.3) | 23 | 4.8 (0.4) | 16 | 4.5 (0.6) | 15 | 0.087 |
| Head translation, mm | 0.29 (0.16) | 27 | 0.27 (0.14) | 17 | 0.24 (0.12) | 17 | 0.447 |
| Head rotation (°) | 0.11 (0.05) | 27 | 0.11 (0.07) | 17 | 0.12 (0.10) | 17 | 0.556 |
| Cog HC | Cog HC versus svPPA | ||||||
| Age | 65.5 (3.0) | 0.2 | |||||
| Gender (M:F) | 10:7 | – | |||||
| Education | 16.8 (2.2) | 0.9 | |||||
| PPT (max 52) | 51.5 (0.6) | 17 | 43.1 (6.5) | 17 | <0.001 | ||
| Reading (max 100) | |||||||
| Regular words | 100.0 (0.0) | 15 | 95.8 (7.5) | 15 | 0.08 | ||
| Irregular words | 99.8 (0.66) | 15 | 75.3(22) | 15 | <0.001 | ||
Shaded areas highlight measures for which patients with semantic variant PPA differ significantly from healthy controls (P < 0.005, two sample t-test).
CDR = Clinical Dementia Rating; MMSE = Mini-Mental State Examination; BNT = Boston Naming Test; PPVT = Peabody Picture Vocabulary Test; svPPA = semantic variant PPA; PPT = Pyramids and palm tree – Pictures.