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. 2013 Aug 9;23(1):1–11. doi: 10.1093/hmg/ddt387

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Figure 4. — Abrogation of improved left ventricular function at 20 weeks of age in Lmna^H222P/H222P mice with deletion of Erk1. (A) Representative M-mode transthoracic echocardiographic tracings from 20-week-old male Lmna^+/+/Erk1^+/+, Lmna^+/+/Erk1^−/−, Lmna^H222P/H222P/Erk1^+/+ and Lmna^H222P/H222P/Erk1^−/− mice. (B) Graphs showing mean LVEDD, LVESD and FS in 20-week-old male Lmna^+/+/Erk1^+/+ (diamonds), Lmna^+/+/Erk1^−/− (squares), Lmna^H222P/H222P/Erk1^+/+ (circles) and Lmna^H222P/H222P/Erk1^−/− (triangles) mice. Values for each individual mouse as well as means (long horizontal bars) and standard errors are shown. ^#P < 0.05; ^###P < 0.0005; n.s., not significant. (C) Expression of Nppa mRNA in hearts from 20-week-old Lmna^+/+/Erk1^+/+, Lmna^+/+/Erk1^−/−, Lmna^H222P/H222P/Erk1^+/+ and Lmna^H222P/H222P/Erk1^−/− mice. Values represent fold change compared with Nppa mRNA in hearts of Lmna^H222P/H222P/Erk1^+/+ mice and are given as means ± standard errors in Lmna^+/+/Erk1^+/+ (n = 4), Lmna^+/+/Erk1^−/− (n = 4), Lmna^H222P/H222P/Erk1^+/+ (n = 3) and Lmna^H222P/H222P/Erk1^−/− (n = 5) mice. ^###P < 0.0005; ***P < 0.0005; n.s., not significant. (D) Expression of Nppb mRNA in hearts from 20-week-old Lmna^+/+/Erk1^+/+, Lmna^+/+/Erk1^−/−, Lmna^H222P/H222P/Erk1^+/+ and Lmna^H222P/H222P/Erk1^−/− mice. Values represent fold change compared with Nppb mRNA in hearts of Lmna^H222P/H222P/Erk1^+/+ mice and are given as means ± standard errors in Lmna^+/+/Erk1^+/+ (n = 4), Lmna^+/+/Erk1^−/− (n = 4), Lmna^H222P/H222P/Erk1^+/+ (n = 3) and Lmna^H222P/H222P/Erk1^−/− (n = 5) mice. ^###P < 0.0005; ***P < 0.0005; n.s., not significant.