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. 2013 Aug 9;23(1):1–11. doi: 10.1093/hmg/ddt387

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Figure 8. — Increased activation p38α and JNK in hearts of 20-week-old Lmna^H222P/H222P mice lacking Erk1. (A) Representative immunoblots using antibodies against phosphorylated p38α (pp38), total p38α (p38), phosphorylated JNK (pJNK) and total JNK (JNK) to probe proteins extracted from hearts of 16-week-old and 20-week-old Lmna^+/+/Erk1^−/− and Lmna^H222P/H222P/Erk1^−/− mice. (B) Bar graphs showing quantification of the ratio of phosphorylated p38α to total p38α (pp38/p38) in hearts of 16-week-old and 20-week-old Lmna^+/+/Erk1^−/− and Lmna^H222P/H222P/Erk1^−/− mice. Values are means ± standard errors (n = 3). **P < 0.0005; n.s., not significant. (C) Bar graphs showing quantification of the ratio of phosphorylated JNK to total JNK (pJNK/JNK) in hearts of 16-week-old and 20-week-old Lmna^+/+/Erk1^−/− and Lmna^H222P/H222P/Erk1^−/− mice. Values are means ± standard errors (n = 3). ***P < 0.0005; n.s., not significant.