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Echocardiographic data for 20-week-old male LmnaH222P/H222P/Erk1−/− mice treated with DMSO or selumetinib
| Treatment | n | Heart rate (beats/ min) | LVEDD (mm) | LVESD (mm) | FS (%) |
|---|---|---|---|---|---|
| DMSO | 15 | 500 ± 1 | 4.5 ± 0.2 | 3.8 ± 0.2 | 16.8 ± 1.6 |
| Selumetinib | 8 | 500 ± 1 | 3.5 ± 0.1*** | 2.4 ± 0.1*** | 31.3 ± 1.8*** |
Values are means ± standard errors; ***P < 0.0005 for comparison between DMSO and selumetinib-treated LmnaH222P/H222P/Erk1−/− mice.
