Table 4.

Functional categories significantly enriched for genes associated with prognosis of newly treated epilepsy by both ALIGATOR and pathMaster

GWAS P-value	Category ID	Pathway length	Expected overlap	Observed overlap	ALIGATOR P-value	pathMaster P-value	Biological function
0.0001	hsa04020	174	0.7	4	0.0052	0.03	Calcium signalling pathway
0.0001	hsa04070	78	0.3	3	0.005	0.043	Phosphatidylinositol signalling system
0.001	GO:0008270	209	5.3	16	0.0002	0.021	Zinc ion binding
0.001	GO:0046870	8	0.2	8	0.0002	0.045	Cadmium ion binding
0.0001	GO:0030262	27	0.0	2	0.001	0.001	Apoptotic nuclear change

ALIGATOR and pathMaster P-value = pathway enrichment P-value.

Proposed biological functions were provided by the Gene Ontology (prefixed by GO) and KEGG databases (prefixed by hsa).

Pathway length, expected overlap and observed overlap refer to ALIGATOR statistics.