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. Author manuscript; available in PMC: 2013 Dec 10.
Published in final edited form as: Future Microbiol. 2011 Dec;6(12):10.2217/fmb.11.137. doi: 10.2217/fmb.11.137

Figure 3. Model of latency-associated nuclear antigen binding to Kaposi’s sarcoma-associated herpesvirus episome and cellular chromosomes.

Figure 3

The C-terminal region of LANA (C) mediates self-association, binds to KSHV terminal repeat DNA in the KSHV episome, and binds to a putative protein (X) that associates with DNA (light gray line). The N-terminal domain of LANA (N) binds to core histones H2A/H2B, which are part of nucleosomes that also contain a H3/H4 histone tetramer.

KSHV: Kaposi’s sarcoma-associated herpesvirus; LANA: Latency-associated nuclear antigen.

Adapted from [51].