Table 4.

The multivariable Cox association between resting heart rate, chronotropic index, and the risk of all-cause mortality

Model	Variable	Adjusted (n = 933)
		Hazard ratio (95% confidence interval)	Chi-square	P-value
1	Resting HR, hazard ratio for 5 b.p.m. increase	1.03 (0.96, 1.12)	0.7	0.42
	CI, hazard ratio for 0.1 decrease below 0.6	1.17 (1.01, 1.36)	4.4	0.036
2	Resting HR, hazard ratio for 5 b.p.m. increase	1.02 (0.94, 1.10)	0.3	0.61
	CI, hazard ratio for CI ≤ 0.62	1.12 (0.72, 1.76)	0.3	0.62
3	Resting HR, hazard ratio for 5 b.p.m. increase	1.03 (0.95, 1.11)	0.4	0.53
	Keteyian CI, hazard ratio for 0.1 decreasea	1.06 (0.99, 1.13)	3.0	0.085

Each model was adjusted for the following covariates: CPX test duration, BMI, creatinine, sex, loop diuretic dose, LVEF, the CCS Angina Class, and ventricular conduction prior to the CPX test.

^aModels including the Keteyian CI include 928 patients, because 5 patients were missing whether the CPX was a bike or treadmill test.