Table 3.
Differences in vascular changes in Alzheimer’s disease compared to the different groups in the analysis adjusted for age at death and gender
| Variable | FTLD-Tau | FTLD-TDP | α-Synucleinopathy | Hippocampal sclerosis | Prion | Unremarkable brain | Cerebrovascular disease |
|---|---|---|---|---|---|---|---|
| Large infarcts | 2.0 (0.006) | 2.3 (0.036) | 1.4 (0.10) | 0.9 (0.79) | –a | 1.5 (0.12) | 0.42 (<0.0001) |
| Multiple microinfarcts | 2.4 (<0.0001) | 2.4 (0.004) | 2.0 (0.0006) | 0.6 (0.79) | –a | 1.5 (0.06) | 0.4 (<0.0001) |
| Lacunes | 1.3 (0.17) | 2.3 (0.01) | 1.3 (0.19) | 0.7 (0.19) | –a | 1.5 (0.05) | 0.4 (<0.0001) |
| Arteriosclerotic leukoencephalopathy | 1.6 (0.07) | 1.5 (0.20) | 1.1 (0.74) | 0.3 (0.004) | –a | 5.5 (0.003) | 0.2 (<0.0001) |
| Haemorrhage | 2.1 (0.03) | 1.9 (0.15) | 1.4 (0.26) | 1.9 (0.30) | –a | 1.8 (0.10) | 0.6 (0.022) |
| Atherosclerosis | 1.4 (0.02) | 1.2 (0.38) | 1.4 (0.01) | 1.0 (0.89) | 4.0 (0.004) | 2.8 (<0.0001) | 0.7 (0.006) |
| Arteriolosclerosis | 1.3 (0.13) | 2.4 (0.0001) | 1.6 (0.005) | 0.7 (0.22) | 4.8 (0.0005) | 3.6 (<0.0001) | 0.4 (<0.0001) |
| Cerebral amyloid angiopathy | 12.4 (<0.0001) | 9.2 (<0.0001) | 6.6 (<0.0001) | 9.1 (<0.0001) | 20.0 (<0.0001) | 6.2 (<0.0001) | 7.2 (<0.0001) |
Data are represented as OR (P-values).
aThis disease presented a low prevalence of changes and/or small sample size and could not be studied in the logistic regression model.