Figure 9. Late-disrupted modules in the EC region.

(A) The histone acetyltransferase-associated module, which is the late-disrupted module with the largest number of disappearing interactions. (B) The RNA polymerase-associated module, which is the late-disrupted module with the second largest number of disappearing interactions. (C) The proteasome-associated module, which is the late-disrupted module sharing the largest number of disappearing interactions with the histone acetyltransferase-associated module. (D) The transcription factor-associated module is the late-disrupted module sharing the largest number of disappearing interactions with the RNA polymerase-associated module. The large nodes are hub proteins with more than 10 disappearing interactions in the module. Links in red and blue indicate disappearing interactions and the other, respectively. These modules are depicted by the superimposition of modules in AD that corresponded with normal aging.