. Author manuscript; available in PMC: 2013 Dec 10.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2012 May 7;21(7):10.1158/1055-9965.EPI-12-0310. doi: 10.1158/1055-9965.EPI-12-0310

Table 3.

Total and direct effects for BMI and alcohol consumption and indirect effects of estradiol on breast cancer derived from linear regression parameter estimates and the additive hazard model

	DE(95%CI)×10⁻⁵	IE (95% CI) ×10⁻⁵	TE (95% CI) ×10⁻⁵	IE/TE (95% CI)
BMI (5-unit increase)	38.0 (8.1–68.1)	11.9 (1.7–22.6)	50.0 (23.2–76.6)	0.238 (0.029–0.684)
Alcohol consumption
Abstainers → <7 drinks/wk	48.8 (−18.2 to 115.7)	−0.3(−5.0 to 4.2)	48.6 (−18.7 to 115.6)	−0.006 (−0.311 to 0.278)
Abstainers → 7+ drinks/wk	174.0 (55.3 to 292.2)	4.3 (−1.8 to 13.5)	178.3 (59.5 to 296.7)	0.024(−0.012 to 0.107)

NOTE: Adjusted for age, ethnicity, educational level, marital status, physical activity, smoking, age at menarche, age at menopause, parity, age at first child's birth, and first-degree relative with breast cancer.