. Author manuscript; available in PMC: 2013 Dec 10.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2012 May 7;21(7):10.1158/1055-9965.EPI-12-0310. doi: 10.1158/1055-9965.EPI-12-0310

Table 4.

Total and direct effects for BMI and alcohol consumption and indirect effects of estradiol on ER-positive and -negative breast cancers]

	DE (95% CI) × 10 ⁻⁵	IE (95% CI) × 10 ⁻⁵	TE (95% CI) × 10 ⁻⁵	IE/TE (95% CI)
ER-positive breast cancers (n = 401)
BMI (5-unit increase)	16.9 (−7.4 to 41.1)	16.1 (7.5–25.2)	33.0 (10.3–55.5)	0.488 (0.188–1.611)
Alcohol consumption
Abstainers → <7 drinks/wk	58.0 (−0.3 to 116.2)	−0.3 (−6.3 to 5.7)	57.8 (−0.9 to 116.3)	−0.005 (−0.255 to 0.191)
Abstainers → 7+ drinks/wk	183.0 (76.0–289.6)	5.8 (−2.9 to 16.7)	188.9 (81.4–296.0)	0.031 (−0.017 to 0.110)
ER-negative breast cancers (n = 163)
BMI (5-unit increase)	15.2 (0.9–29.6)	−3.0 (−7.9 to 1.7)	12.1 (−0.1 to 24.4)	−0.248 (−1.430 to 0.468)
Alcohol consumption
Abstainers → <7 drinks/wk	−11.9 (−41.7 to 17.8)	0.1 (−1.6 to 1.8)	−11.9 (−41.6 to 17.9)	−0.008 (−0.394 to 0.398)
Abstainers → 7+ drinks/wk	−31.0 (−72.0 to 9.8)	−1.1 (−4.9 to 1.1)	−32.1 (−73.0 to 8.7)	0.034 (−0.199 to 0.367)

NOTE: Adjusted for age, ethnicity, educational level, marital status, physical activity, smoking, age at menarche, age at menopause, parity, age at first child's birth, and first-degree relative with breast cancer.