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Treatments of normal human lung cells with Co(II) and Ni(II). Cells were treated with metals for 24h. Data are means ± SD for at least 3 independent determinations. A, Accumulation of metals by IMR90 normal human fibroblasts and B, primary HBE cells. C, Caspase activity in HBE cells after 24-h exposure to metals. D, Caspase activity in HBE cells at 24h postexposure to Co(II) (***p < 0.001 relative to untreated cells).
