Table 2.

A partial list of ECM, chemokines, cytokines, and substrates degraded, activated or inactivated by MMP-9

MMP-9	Substrate
Degrades	Collagen type I, II, III, IV, V, XI, XVI, fibronectin, laminin, osteopontin, thrombospondin-1, tenascin-C, galectin-3, decorin
Activates	CXCL5, CXCL8, TNF-α, IL-1β, TGF-β
Inactivates	CXCL1, CXCL4, CXCL5, CXCL7, CXCL12, IL-1β

A partial list of ECM, chemokines, cytokines, and substrates degraded, activated or inactivated by MMP-9 (20, 23, 25, 31, 33–34, 36, 54, 58–59, 61, 64, 79, 84, 89, 92-92, 106, 109, 111). IL, interleukin; TNF-α, tumor necrosis factor α; TGF-β, transforming growth factor β; CXCL, chemokine (C-X-C motif) ligand.