Table 3.
Effects of intracardiac-injected substances on myocardial structure and function after injury
| Substance Injected | Effects |
|---|---|
| ECM-derived Hep I | Promotes cell attachment, migration, and proliferation; induces Erk1/2 activation; promotes angiogenesis and arteriogenesis |
| ECM-derived Hep III | Promotes cell attachment, migration, and proliferation; induces Erk1/2 activation; promotes angiogenesis and arteriogenesis; prevents worsening of LV function; interacts with other Hep III peptides and ECM proteins; forms polymer-like matrix |
| ECM-derived RDG | Promotes cell attachment, migration, and proliferation; induces Erk1/2 activation; promotes angiogenesis and arteriogenesis |
| ECM-derived FC/HV | Adherent cells noticeable within 24 h; induces Erk1/2 activation |
| Injection of decellularized matrix | Thickens the LV infarcted wall; prevents LV systolic dysfunction; improves EF |
| Fibrin | Preserves infarcted wall thickness and cardiac function |
| Tannic acid | Prevents collagen degradation via cross-linking; inhibits MMP-9 activity |