. 2013 Dec 10;8(12):e81492. doi: 10.1371/journal.pone.0081492

Table 3. Drug sensitivity profile against Leishmania donovani wild-type, drug resistant and field isolated intracellular amastigote cell lines.

Drug	IC₅₀ (mean ± SD for atleast 4 replicates) µM^a
	Cellular AG83 evaluation model								Cellular GE1 evaluation model
	Wild-type	SI^f	SSGresistant^b	RI^c	SI^f	PMMresistant^b	RI^c	SI^f	Fieldisolate	RI^d	SI^f	CytotoxicityCC₅₀ (µM)(Macrophagecells)
Amphotericin B	0.15±0.05^g	93	0.2±0.05^g	1.3	70	0.20±0.05^g	1.3	68	0.16±0.05^g	1.06	87.5	14±2.1^h
SSG(SbV)^e	1.6±0.20	17	18.1±3^g	11.2	1.5	17.3±2.60	10.8	1.6	7.7±0.65	4.8	3.5	27±3.9
PMM	8±2^g	31	125±15^g	15.6	2	115±13^g	14.4	2.1	18±3^g	2.2	13.8	248±32^g
AG	141±20^g	7.1	230±25^g	1.6	4.3	200±30^g	1.4	5	165±27^g	1.2	6.1	1000±160^g
AGnp with TPGS	28±2^g	71.4	60±9^g	2.1	33.3	49±6^g	1.8	40.8	42±5^g	1.5	47.6	2000±300^g
AGnp without TPGS	54±5^g	22.2	120±10^g	2.2	10	107±8^g	2	11.2	83±9^g	1.5	14.4	1200±220^g

^a Assays are described in Materials and Methods.

in vitro as given in Materials and Methods.^b SSG and PMM resistant strains were generated

₅₀ of AG83 phenotype generated at maximum drug pressure/IC₅₀ of wild-type.^c RI, Resistance Index was IC

₅₀ of field isolate/IC₅₀ of wild-type.^d RI, Resistance Index was IC

µg Sb/ml.^e Values for antimonial agents are in

₅₀/IC₅₀.^f SI, Selectivity Index was CC

^g p<0.001, significant difference compared with SSG.

^h p<0.5, no significant difference compared with SSG.