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. 2013 Dec 10;8(12):e82968. doi: 10.1371/journal.pone.0082968

Figure 10. Anti-apoptosis effect of klotho was dependent on MAPK.

Figure 10

(A) Representative images of apoptosis assay assessed by flow cytometry in H9c2 cells treated by ISO, ISO+KL, ISO+SB203580, ISO+PD98059, and ISO+SP600125. (B) Demonstration of apoptosis rate in ISO, ISO+KL, ISO+SB203580, ISO+PD98059, and ISO+SP600125 groups. (C) Representative images of western blotting of GRP78, HSP47, CHOP and beta-actin in ISO, ISO+KL, ISO+SB203580, ISO+PD98059, and ISO+SP600125 groups. (D,E,F) Demonstration of the expression level of GRP78(D), HSP47(E) and CHOP(F) in ISO, ISO+KL, ISO+SB203580, ISO+PD98059, and ISO+SP600125 groups. Data are mean±SEM, n=3. * P<0.05 between two compared groups; NS, no significance.