Table 2. Radiaton and chemotherapy pathway gene polymorphisms and survival in patients with NPC treated with cisplatin/5-FU based CRT.
| Pathway a | Gene | SNP | Genotype |
Overall survival
|
Progression-free survival
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dead/Alive | HR (95%CI) b | P b | Q | Failure/No | HR (95%CI) b | P b | Q | ||||
| R+D | FGFR4 | rs351855 | |||||||||
| CC | 32/81 | Ref | 40/73 | Ref | |||||||
| CT | 59/152 | 0.952 (0.704-1.288) | 0.751 | 72/139 | 0.983 (0.668-1.448) | 0.933 | |||||
| TT | 21/68 | 0.824 (0.558-1.216) | 0.330 | 22/67 | 0.680 (0.404-1.144) | 0.680 | |||||
| CT/TT | 80/220 | 0.916 (0.686-1.223) | 0.551 | 94/206 | 0.890 (0.615-1.289) | 0.539 | |||||
| Model-free test c | 0.608 | 0.578 | 0.273 | 0.428 | |||||||
| D+F | ERCC1 | rs3212986 | |||||||||
| CC | 78/196 | Ref | 104/170 | Ref | |||||||
| CA | 27/82 | 0.842 (0.542-1.306) | 0.442 | 25/84 | 0.567 (0.366-0.878) | 0.011 | |||||
| AA | 8/24 | 1.049 (0.505-2.177) | 0.898 | 7/25 | 0.597 (0.277-1.284) | 0.186 | |||||
| CA/AA | 35/106 | 0.882 (0.591-1.316) | 0.538 | 32/109 | 0.573 (0.385-0.853) | 0.006 | |||||
| Model-free test c | 0.721 | 0.578 | 0.023 | 0.105 | |||||||
| D+F | ERCC2 | rs1799793 | |||||||||
| GG | 104/263 | Ref | 123/244 | Ref | |||||||
| AG | 7/37 | 0.683 (0.317-1.470) | 0.785 | 10/34 | 0.727 (0.381-1.387) | 0.333 | |||||
| AA | 1/4 | 1.315 (0.183-9.473) | 0.329 | 1/4 | 0.823 (0.115-5.901) | 0.846 | |||||
| AG/AA | 8/41 | 0.726 (0.353-1.494) | 0.384 | 11/38 | 0.735 (0.396-1.364) | 0.329 | |||||
| Model-free test c | 0.590 | 0.578 | 0.617 | 0.641 | |||||||
| D+F | ERCC2 | rs13181 | |||||||||
| TT | 93/252 | Ref | 114/231 | Ref | |||||||
| GT | 17/47 | 1.067 (0.636-1.791) | 0.806 | 18/46 | 0.871 (0.530-1.433) | 0.587 | |||||
| GG | 1/3 | 0.717 (0.100-5.151) | 0.741 | 2/2 | 1.344 (0.331-5.454) | 0.679 | |||||
| GT/GG | 18/50 | 1.039 (0.627-1.721) | 0.883 | 20/48 | 0.903 (0.562-1.453) | 0.675 | |||||
| Model-free test c | 0.915 | 0.596 | 0.783 | 0.715 | |||||||
| R+D+F | XRCC1 | rs25487 | |||||||||
| GG | 57/173 | Ref | 68/162 | Ref | |||||||
| AG | 41/110 | 1.133 (0.759-1.693) | 0.541 | 51/100 | 1.158 (0.805-1.665) | 0.428 | |||||
| AA | 13/20 | 1.797 (0.983-3.285) | 0.057 | 14/19 | 1.587 (0.892-2.823) | 0.116 | |||||
| AG/AA | 54/130 | 1.243 (0.857-1.804) | 0.251 | 65/119 | 1.230 (0.875-1.728) | 0.234 | |||||
| Model-free test c | 0.156 | 0.576 | 0.270 | 0.428 | |||||||
| F | MTHFR | rs1801131 | |||||||||
| AA | 55/166 | Ref | 65/156 | Ref | |||||||
| AC | 49/115 | 1.252 (0.851-1.840) | 0.254 | 60/104 | 1.331 (0.937-1.892) | 0.111 | |||||
| CC | 8/21 | 1.148 (0.547-2.410) | 0.716 | 9/20 | 1.117 (0.556-2.244) | 0.756 | |||||
| AC/CC | 57/136 | 1.236 (0.853-1.790) | 0.263 | 69/124 | 1.298 (0.925-1.823) | 0.131 | |||||
| Model-free test c | 0.518 | 0.578 | 0.280 | 0.428 | |||||||
| F | MTHFR | rs1801133 | |||||||||
| CC | 47/145 | Ref | 55/137 | Ref | |||||||
| CT | 52/119 | 1.300 (0.876-1.930) | 0.193 | 61/110 | 1.293 (0.898-1.863) | 0.167 | |||||
| TT | 12/39 | 0.948 (0.502-1.789) | 0.857 | 18/33 | 1.286 (0.754-2.192) | 0.356 | |||||
| CT/TT | 64/158 | 1.216 (0.834-1.773) | 0.310 | 79/143 | 1.291 (0.915-1.823) | 0.146 | |||||
| Model-free test c | 0.350 | 0.578 | 0.348 | 0.477 | |||||||
| D+F | ABCB1 | rs1045642 | |||||||||
| CC | 44/106 | Ref | 48/102 | Ref | |||||||
| CT | 51/151 | 0.895 (0.597-1.343) | 0.593 | 66/136 | 1.064 (0.734-1.543) | 0.744 | |||||
| TT | 19/48 | 1.083 (0.631-1.859) | 0.771 | 22/45 | 1.064 (0.642-1.762) | 0.811 | |||||
| CT/TT | 70/199 | 0.940 (0.643-1.374) | 0.748 | 88/181 | 1.064 (0.748-1.512) | 0.730 | |||||
| Model-free test c | 0.742 | 0.578 | 0.942 | 0.782 | |||||||
| D+F | ABCB1 | rs2032582 | |||||||||
| GG | 30/78 | Ref | 35/73 | Ref | |||||||
| GT | 45/121 | 0.987 (0.621-1.567) | 0.955 | 58/108 | 1.095 (0.720-1.666) | 0.672 | |||||
| TT | 20/70 | 0.756 (0.430-1.332) | 0.334 | 22/68 | 0.682 (0.400-1.163) | 0.160 | |||||
| AG | 10/17 | 1.279 (0.623-2.623) | 0.502 | 8/19 | 0.870 (0.403-1.878) | 0.723 | |||||
| AT | 7/11 | 1.608 (0.704-3.673) | 0.259 | 10/8 | 2.398 (1.185-4.853) | 0.015 | |||||
| AA | 0/5 | 2/3 | 1.150 (0.276-4.785) | 0.848 | |||||||
| GT/TT/AG/AT/AA | 0.953 (0.627-1.449) | 0.822 | 0.996 (0.678-1.464) | 0.984 | |||||||
| Others vs. AT/AA | 1.207 (0.560-2.598) | 0.631 | 2.132 (1.176 -3.863) | 0.013 | |||||||
| Model-free test c | 0.591 | 0.578 | 0.046 | 0.157 | |||||||
| D | MPO | rs2243828 | |||||||||
| TT | 63/245 | Ref | 71/237 | Ref | |||||||
| CT | 39/59 | 2.131 (1.428-3.178) | 2.09E-4 | 53/45 | 2.779 (1.946-3.970) | 1.91E-8 | |||||
| CC | 11/1 | 8.994 (4.720-17.136) | 2.42E-11 | 12/0 | 12.041 (6.457-22.454) | 5.03E-15 | |||||
| CT/CC | 50/60 | 2.561 (1.776-3.713) | 7.14E-7 | 65/45 | 3.226 (2.302-4.521) | 1.01E-11 | |||||
| Model-free test c | 1.88E-11 | 2.08E-10 | 4.03E-17 | 5.52E-16 | |||||||
| R | hOGG1 | rs1052133 | |||||||||
| GG | 39/106 | Ref | 44/101 | Ref | |||||||
| CG | 57/148 | 1.045 (0.695-1.572) | 0.832 | 76/129 | 1.257 (0.886-1.825) | 0.228 | |||||
| CC | 16/49 | 0.899 (0.502-1.609) | 0.720 | 15/50 | 0.725 (0.404-1.304) | 0.283 | |||||
| CG/CC | 73/197 | 1.009 (0.683-1.490) | 0.964 | 91/179 | 1.121 (0.781-1.608) | 0.536 | |||||
| Model-free test c | 0.867 | 0.596 | 0.114 | 0.312 | |||||||
| R | APEX1 | rs1130409 | |||||||||
| TT | 47/107 | Ref | 52/102 | Ref | |||||||
| GT | 51/151 | 0.824 (0.554-1.225) | 0.338 | 64/138 | 0.962 (0.667-1.387) | 0.835 | |||||
| GG | 14/44 | 0.805 (0.443-1.462) | 0.476 | 19/39 | 1.011 (0.597-1.709) | 0.969 | |||||
| GT/GG | 65/195 | 0.820 (0.563-1.193) | 0.278 | 83/177 | 0.973 (0.688-1.376) | 0.875 | |||||
| Model-free test c | 0.582 | 0.578 | 0.970 | 0.782 | |||||||
| R | ADPRT | rs1136410 | |||||||||
| TT | 40/89 | Ref | 46/83 | Ref | |||||||
| CT | 51/156 | 0.796 (0.526-1.204) | 0.280 | 63/144 | 0.834 (0.570-1.220) | 0.349 | |||||
| CC | 22/56 | 0.928 (0.552-1.562) | 0.779 | 27/51 | 1.023 (0.636-1.646) | 0.926 | |||||
| CC/CT | 73/212 | 0.832 (0.565-1.223) | 0.349 | 90/195 | 0.883 (0.618-1.260) | 0.491 | |||||
| Model-free test c | 0.544 | 0.578 | 0.541 | 0.618 | |||||||
| D | MDM2 | rs2279744 | |||||||||
| TT | 18/80 | Ref | 21/77 | Ref | |||||||
| GT | 49/134 | 1.586 (0.923-2.722) | 0.095 | 61/122 | 1.735 (1.056-2.851) | 0.030 | |||||
| GG | 46/89 | 2.041 (1.183-3.521) | 0.010 | 54/81 | 2.127 (1.284-3.524) | 0.003 | |||||
| GT/GG | 95/223 | 1.778 (1.074-2.943) | 0.025 | 115/203 | 1.899 (1.192-3.026) | 0.007 | |||||
| Model-free test c | 0.036 | 0.199 | 0.014 | 0.096 | |||||||
| D | VEGF | rs2010963 | |||||||||
| GG | 45/113 | Ref | 48/110 | Ref | |||||||
| CG | 47/146 | 0.877 (0.583-1.321) | 0.530 | 61/132 | 1.069 (0.732-1.561) | 0.729 | |||||
| CC | 20/45 | 1.084 (0.640-1.836) | 0.764 | 25/40 | 1.254 (0.773-2.035) | 0.359 | |||||
| CG/CC | 67/191 | 0.930 (0.637-1.358) | 0.708 | 86/172 | 1.117 (0.784-1.591) | 0.539 | |||||
| Model-free test c | 0.687 | 0.578 | 0.655 | 0.641 | |||||||
| D | VEGF | rs833061 | |||||||||
| TT | 58/167 | Ref | 70/155 | Ref | |||||||
| CT | 49/124 | 1.144 (0.782-1.673) | 0.489 | 60/113 | 1.159 (0.821-1.637) | 0.401 | |||||
| CC | 5/12 | 1.119 (0.448-2.794) | 0.809 | 4/13 | 0.721 (0.263-1.975) | 0.524 | |||||
| CT/CC | 54/136 | 1.141 (0.788-1.673) | 0.485 | 64/126 | 1.117 (0.796-1.568) | 0.523 | |||||
| Model-free test c | 0.783 | 0.578 | 0.519 | 0.618 | |||||||
| D | VEGF | rs3025039 | |||||||||
| CC | 79/212 | Ref | 100/191 | Ref | |||||||
| CT | 32/83 | 0.951 (0.630-1.435) | 0.811 | 31/84 | 0.721 (0.481-1.079) | 0.111 | |||||
| TT | 1/7 | 0.387 (0.054-2.780) | 0.345 | 3/5 | 0.957 (0.303-3.021) | 0.941 | |||||
| CT/TT | 33/90 | 0.883 (0.586-1.332) | 0.553 | 34/89 | 0.482 (0.644-1.060) | 0.095 | |||||
| Model-free test c | 0.630 | 0.578 | 0.281 | 0.428 | |||||||
a R, Radiation; D, DDP; F, 5-Fluorouracil
b HR, 95%CI and P values were calculated by using Cox proportional hazard model with no adjustment.
c The association analysis was done based on the genetic model-free test (2 degrees of freedom)