Table 3. Effect of LCMF on colonization, persistence and survival during Salmonella enterocolitis.
| Treatment | Dose CFU/mice | Days p.i. | Peyer´s Patches (CFU/ml)(a) | Spleen (CFU/ml)(a) | Survival rate(b) |
|---|---|---|---|---|---|
| EC | 3-4 x 103 | 2 | 52 (19-78) | 65 (23-89) | 5/5 |
| 5 | 66 (24-113) | 88 (32-111) | 4/5 | ||
| 14 | Negative | 55 (17-63) | 4/5 | ||
| L. casei + EC | 3-4 x 103 | 2 | <5* | <5 | 5/5 |
| 5 | <5 | <5 | 5/5 | ||
| 14 | Negative | Negative | 5/5 |
Mice received 20 mg of streptomycin 24 h before intragastric infection with 3-4 x 103 CFU of Salmonella enterica (EC group). L. casei + EC group received probiotic for a week before EC onset. At day 2, 5 and 14 after infection mice were sacrificed.
(a) Median (range). * S. Enteritidis was isolated only after enrichment in selenite broth. Survival rate: Number of survivors/total number of mice.
(b) Number of survivors/total number of mice.