Figure 3. C-terminal globular domains of all three human type V myosins potentially mediate autoinhibition.

(A) Surface representation of Myo5a GD with residues K1708 and K1781 highlighted in red. Their mutation resulted in a loss of autoinhibition [23]. (B) Comparison of electrostatic surface potentials of K1708 and K1781 (red circles) with identical positions in Myo5b and Myo5c and the conservation of these residues in all three paralogs (Figure S3 in File S1) suggests that autoinhibition might be a general feature of human type V myosins. Figures were generated with the program Pymol.