Table 3. Results for Association with Dizygous (DZ) twinness for SNPs with P-value < 1 × 10-5 in Stage 1.
| Chromosome | SNP | Position (build 36) | Closest Gene | Risk Allele |
Stage 1 - Swedish samples
|
Stage 2 - Finnish samples
|
Meta-analysis - stage 1 + stage 2
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Risk allele frequency | OR (95% CI) | P-value | Risk allele frequency | OR (95% CI) | P-value | OR (95% CI) | P-value | |||||
| 2 | rs10928585 | 137768012 | THSD7B | A | 0.07 | 0.73 (0.65-0.82) | 1.96E-07 | 0.06 | 0.83 (0.63-1.08) | 1.71E-01 | 0.74 (0.67-0.83) | 8.04E-08 |
| 2 | rs2961957 | 155618326 | KCNJ3 | G | 0.52 | 0.85 (0.78-0.92) | 9.45E-06 | 0.51 | 1.00 (0.88-1.15) | 9.71E-01 | 0.91 (0.78-1.07) | 2.62E-01 |
| 3 | rs936839 | 127498978 | MGLL | T | 0.08 | 0.77 (0.69-0.86) | 3.60E-06 | 0.09 | 1.10 (0.86-1.40) | 4.43E-01 | 0.90 (0.64-1.28) | 5.72E-01 |
| 5 | rs260409 | 1887817 | - | T | 0.19 | 1.19 (1.11-1.29) | 6.49E-06 | 0.19 | 0.83 (0.69-0.99) | 4.00E-02 | 1.00 (0.70-1.43) | 9.95E-01 |
| 6 | rs1554783 | 152877077 | SYNE1 | G | 0.25 | 1.21 (1.12-1.29) | 1.78E-07 | 0.28 | 0.94 (0.81-1.10) | 4.40E-01 | 1.08 (0.84-1.38) | 5.47E-01 |
| 7 | rs2237562 | 86422232 | GRM3 | C | 0.28 | 0.86 (0.81-0.92) | 5.38E-06 | 0.31 | 1.01 (0.87-1.16) | 9.38E-01 | 0.92 (0.79-1.07) | 2.62E-01 |
| 7 | rs10268314 | 87169669 | ABCB1 | C | 0.11 | 0.79 (0.72-0.87) | 1.21E-06 | 0.06 | 0.93 (0.70-1.23) | 5.83E-01 | 0.81 (0.72-0.91) | 3.73E-04 |
| 9 | rs2033541 | 18789352 | ADAMTSL1 | A | 0.29 | 0.83 (0.78-0.88) | 1.41E-08 | 0.23 | 0.87 (0.74-1.02) | 7.80E-02 | 0.84 (0.79-0.89) | 5.37E-09 |
| 9 | rs4149283 | 107626189 | ABCA1 | T | 0.03 | 0.62 (0.52-0.74) | 4.30E-08 | 0.04 | 0.77 (0.52-1.11) | 1.69E-01 | 0.64 (0.55-0.75) | 3.78E-08 |
| 9 | rs7035023 | 133797557 | FIBCD1 | C | 0.21 | 0.85 (0.79-0.91) | 8.02E-06 | 0.21 | 1.00 (0.85-1.17) | 9.65E-01 | 0.90 (0.78-1.05) | 1.96E-01 |
| 10 | rs7905434 | 1567107 | ADARB2 | G | 0.45 | 0.87 (0.82-0.93) | 7.58E-06 | 0.39 | 0.97 (0.84-1.11) | 6.03E-01 | 0.90 (0.82-0.99) | 2.68E-02 |
| 10 | rs11593057 | 14887979 | HSPA14 | T | 0.15 | 0.82 (0.76-0.90) | 4.01E-06 | 0.14 | 0.99 (0.83-1.20) | 9.06E-01 | 0.88 (0.74-1.05) | 1.65E-01 |
| 10 | rs564281 | 29441347 | - | T | 0.44 | 1.17 (1.10-1.24) | 4.88E-07 | 0.48 | 1.00 (0.88-1.15) | 9.80E-01 | 1.10 (0.94-1.27) | 2.31E-01 |
| 10 | rs534371 | 29441360 | - | G | 0.49 | 1.16 (1.09-1.23) | 1.57E-06 | 0.52 | 0.98 (0.86-1.12) | 7.64E-01 | 1.08 (0.91-1.27) | 3.73E-01 |
| 10 | rs7081193 | 128074225 | ADAM12 | C | 0.07 | 0.77 (0.68-0.86) | 4.91E-06 | 0.07 | 1.17 (0.91-1.50) | 2.16E-01 | 0.94 (0.62-1.41) | 7.48E-01 |
| 12 | rs7955592 | 29778035 | TMTC1 | A | 0.26 | 1.18 (1.10-1.26) | 5.34E-06 | 0.26 | 0.99 (0.85-1.15) | 8.42E-01 | 1.09 (0.92-1.30) | 3.23E-01 |
| 15 | rs3784415 | 88653481 | NTRK3 | C | 0.10 | 0.8 (0.73-0.88) | 7.32E-06 | 0.07 | 1.11 (0.85-1.44) | 4.38E-01 | 0.92 (0.67-1.26) | 6.07E-01 |
In-silico replication in stage 2 and meta-analysis of the two stages.
OR and P-values are obtained from logistic regressions adjusted for birth year, sex and 3 MSC’s or from random-effect meta-analysis