Table 4. Results for Association with Monozygous (MZ) twinness for SNPs with P-value < 1 × 10-5 in Stage 1.
| Chromosome | SNP | Position (build 36) | Closest Gene | Risk Allele |
Stage 1 - Swedish samples
|
Stage 2 - Finnish samples
|
Meta-analysis - stage 1 + stage 2
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Risk allele frequency | OR (95% CI) | P-value | Risk allele frequency | OR (95% CI) | P-value | OR (95% CI) | P-value | |||||
| 2 | rs11891511 | 240644907 | - | G | 0.18 | 1.28 (1.15-1.43) | 7.66E-06 | 0.18 | 0.91 (0.70-1.78) | 0.474 | 1.10 (0.79-1.54) | 5.68E-01 |
| 7 | rs10487484 | 127105414 | - | C | 0.11 | 1.36 (1.19-1.55) | 9.10E-06 | 0.16 | 1.04 (0.80-1.36) | 0.754 | 1.22 (0.95-1.57) | 1.25E-01 |
| 14 | rs1152790 | 99710843 | BCL11B | T | 0.50 | 1.18 (1.11-1.25) | 6.77E-06 | 0.49 | 1.10 (0.90-1.34) | 0.363 | 1.17 (1.08-1.26) | 1.75E-04 |
| 15 | rs8029801 | 102073917 | - | T | 0.18 | 1.30 (1.17-1.45) | 2.31E-06 | 0.19 | 0.73 (0.56-0.95) | 0.02 | 0.99 (0.56-1.74) | 9.61E-01 |
| 17 | rs3826503 | 3474660 | TRPV1 | A | 0.18 | 0.74 (0.66-0.83) | 8.79E-07 | 0.24 | 0.95 (0.75-1.20) | 0.688 | 0.82 (0.65-1.05) | 1.18E-01 |
| 18 | rs4552096 | 74518951 | - | T | 0.43 | 0.81 (0.74-0.89) | 5.68E-06 | 0.41 | 1.13 (0.92-1.39) | 0.233 | 0.95 (0.68-1.31) | 7.41E-01 |
In-silico replication in stage 2 and meta-analysis of the two stages.
OR and P-values are obtained from logistic regressions adjusted for birth year, sex and 3 MSC’s or from random-effect meta-analysis