Table 2.
Change in vasomotor symptoms by exercise arm
| Intent to Treat Analysis1 | N | Exercise Mean (95% CI) |
N | Usual Activity Mean (95% CI) |
Difference Mean (95% CI) |
p-value2 |
|---|---|---|---|---|---|---|
| Hot flashes / day3 | 0.434 | |||||
| Baseline | 106 | 7.3 (6.7, 7.9) | 142 | 8.0 (7.3, 8.7) | −0.7 (−1.6, 0.2) | |
| Week 6 – baseline | 102 | −2.0 (−2.6, −1.4) | 133 | −2.0 (−2.5, −1.4) | −0.1 (−0.9, 0.7) | |
| Week 12 – baseline | 101 | −2.4 (−3.0, −1.7) | 135 | −2.6 (−3.2, −2.0) | 0.2 (−0.6, 1.1) | |
|
| ||||||
| Bother (1–4) | 0.745 | |||||
| Baseline | 106 | 2.9 (2.8, 3.0) | 142 | 3.0 (2.9, 3.1) | −0.1 (−0.2, 0.0) | |
| Week 6 – baseline | 102 | −0.4 (−0.5, −0.3) | 132 | −0.4 (−0.5, −0.3) | 0.0 (−0.1, 0.1) | |
| Week 12 – baseline | 100 | −0.5 (−0.6, −0.4) | 133 | −0.5 (−0.6, −0.4) | 0.0 (−0.1, 0.2) | |
|
| ||||||
| Sensitivity Analysis4 | N | Exercise Mean (95% CI) | N | Usual Activity Mean (95% CI) | Difference Mean (95% CI) | p-value2 |
|
| ||||||
| Hot flashes / day3 | 0.708 | |||||
| Baseline | 106 | 7.3 (6.7, 7.9) | 142 | 8.0 (7.3, 8.7) | −0.7 (−1.6, 0.2) | |
| Week 6 – baseline | 79 | −1.9 (−2.6, −1.2) | 133 | −2.0 (−2.5, −1.4) | 0.0 (−0.9, 0.9) | |
| Week 12 – baseline | 74 | −2.5 (−3.2, −1.7) | 135 | −2.6 (−3.2, −2.0) | 0.1 (−0.8, 1.1) | |
|
| ||||||
| Bother (1–4) | 0.628 | |||||
| Baseline | 106 | 2.9 (2.8, 3.0) | 142 | 3.0 (2.9, 3.1) | −0.1 (−0.2, 0.0) | |
| Week 6 – baseline | 79 | −0.4 (−0.5, −0.3) | 132 | −0.4 (−0.5, −0.3) | 0.0 (−0.1, 0.2) | |
| Week 12 – baseline | 74 | −0.5 (−0.6, −0.4) | 133 | −0.5 (−0.6, −0.4) | 0.0 (−0.2, 0.2) | |
1
includes all participants with follow-up measures, regardless of adherence to intervention
2
p-values from contrasts comparing exercise vs. usual activity in a repeated measures linear model of outcome as a function of intervention arm, clinical center, visit (week 6 or 12), omega-3 intervention assignment, and baseline outcome value. A p-value < 0.025 was considered statistically significant when accounting for the 2 primary outcome comparisons of interest.
3
hot flash frequency values were log transformed for modeling
4
includes only participants with ≥ 80% total session attendance for the given time interval