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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Mol Carcinog. 2013 Aug 31;53(0 1):E130–E139. doi: 10.1002/mc.22054

Figure 7.

Figure 7

Model of calcitriol mediated sensitivity to radiation. In DLD-1 and HCT116 cells, Slug is a negative regulator of E-cadherin. The addition of calcitriol leads to repression of Slug and a subsequent increase in E-cadherin (E Cad) and/or membrane localized E-cadherin resulting in an increased sensitivity to radiation. However, in SW620 cells in which both Slug and vimentin (Vim) are induced with the addition of calcitriol, calcitriol therapy does not increase E-cadherin levels and therefore we see no change in radiation sensitivity.