Table 2.
One-pot, sequential RCM/CM/chemoselective hydrogenation involving type II olefins
| entry | olefin | yield %a (avg %) |
RCM-CM-chemoselective hydrogenation |
|---|---|---|---|
| 1 |
|
41% (75%) |
|
| 2 |
|
35% (71%) |
|
| 3 |
|
69% (89%) |
|
| 4 |
|
48% (78%) |
|
| 5 |
|
72% (90%) |
|
| 6 |
|
30%b (67%) |
|
| 7 |
|
54% (81%) |
|
| 8 |
|
85% (95%) |
|
| 9 |
|
79% (92%) |
|
a
All reactions were performed using freshly distilled (over CaH2) FDT solvents
b
Reaction was performed in CH2Cl2, 1,2-DCE purified by passing through basic Al2O3 and degassed by argon purging.