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. Author manuscript; available in PMC: 2014 Dec 15.
Published in final edited form as: J Immunol. 2013 Nov 6;191(12):10.4049/jimmunol.1302273. doi: 10.4049/jimmunol.1302273

Figure 4. Development of diabetes is not due to increased Foxp3+Treg frequency or suppression.

Figure 4

(A) Frequency of Foxp3+CD25+CD4+ T cells in recipients of different aged NOD thymi (n=7) 6 wk-post implantation or 12 wk-old intact NOD female mice (NOD). (B) In vivo proliferation of cell trace-labeled NOD.BDC2.5 CD4+ T cells 4 d post-transfer in the PLN of recipients of newborn and 4 wk-old NOD thymus 6 wk post-implantation or unmanipulated NOD.scid controls. Data is reported as proliferation index (left) with representative FACS histograms gated on CD3+CD4+cell trace+ T cells (right) (n=5). Error bars represent SEM.