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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Mol Cancer Ther. 2013 Oct 9;12(12):10.1158/1535-7163.MCT-12-0719. doi: 10.1158/1535-7163.MCT-12-0719

Figure 5.

Figure 5

RRD-251 inhibits orthotopic tumor growth and metastasis. A, Mice treated with RRD-251 had a significant decrease in primary orthotopic tumor growth (*p<0.01). B, Representative H&E tumor samples (T) of mice treated with RRD-251 demonstrates the loss of metastases (M) to liver and lymph nodes adjacent to normal tissue (N). C, Expression levels of phospho-Rb (p-Rb) are higher in lymph node and liver metastatic sites (M) of control mice when compared to the unaffected lymph node and liver tissue (N) of mice treated with RRD-251.