Table 2. KMTs involved in regulation of p53 and histones and their functional outcomes.
| Methyltransferase | Target residue in Histones | Functional outcome | Target residue in p53 | Functional outcome |
|---|---|---|---|---|
| SET7/9 | H3K4 me1 | Transcriptional activation | K372 me1 | Up-regulation of p53-target genes |
| SET8 | H4K20 me1 | Transcriptional Repression? | K380 me1 | Transcriptional inactivation |
| SMYD2 | H3K36 me2 | Transcriptional repression | K370 me1 | Transcriptional inactivation |
| G9a/Glp | H3K9 me1 H3K9 me2 H3K27 me1 |
Gene silencing Heterochromatin formation |
K373 me2 | Transcriptional Repression? |
| SMYD3 | H3K4 me2 | Transcriptional activation | ? | ? |
| SETD2 | H3K36 me3 | Gene regulation? | ? | Up-regulation of apoptotic and cell cycle arrest genes |
| SET1 | H3K4 me3 | Chromatin Remodelling Transcriptional activation |
? | ? |