Table 2. Drug transporter SNPs associated with CI-MMR at 18 months.
SNP | Chr. | Coordinate | Transporter gene symbol | SLEC | SVC (P-value) | |||
---|---|---|---|---|---|---|---|---|
P-value | FDR | All | 400 mg/d | 600 mg/d | ||||
rs609468 | 6 | 160498904 | SLC22A1 | <0.001 | 0.001 | 0.920 | 0.210 | 0.090 |
rs10841907 | 12 | 21942563 | ABCC9 | 0.001 | 0.238 | 0.310 | 0.670 | 0.450 |
rs12505410 | 4 | 89249865 | ABCG2 | 0.002 | 0.238 | 0.045* | 0.035* | 0.320 |
rs4149182 | 11 | 62524689 | SLC22A8 | 0.002 | 0.238 | 0.750 | 0.640 | 0.820 |
rs1189451 | 13 | 94520087 | ABCC4 | 0.005 | 0.430 | 0.260 | 0.360 | 0.330 |
rs17556915 | 14 | 69318111 | SLC10A1 | 0.008 | 0.482 | 0.068 | 0.130 | 0.230 |
rs11024300 | 11 | 17452549 | ABCC8 | 0.009 | 0.482 | 0.870 | 0.550 | 0.160 |
rs13120400 | 4 | 89252551 | ABCG2 | 0.012 | 0.482 | 0.140 | 0.046* | 0.740 |
rs2725252 | 4 | 89280934 | ABCG2 | 0.012 | 0.482 | 0.086 | 0.047* | 0.740 |
rs2665691 | 11 | 22327832 | SLC17A6 | 0.012 | 0.482 | 0.075 | 0.110 | 0.360 |
rs1678405 | 13 | 94627682 | ABCC4 | 0.014 | 0.482 | 0.710 | 0.850 | 0.370 |
rs1048099 | 11 | 17453092 | ABCC8 | 0.014 | 0.482 | 0.950 | 0.220 | 0.150 |
Chr., chromosome; FDR, false discover rate; SNP, single nucleotide polymorphism
Significant association between CI-MMR and SNP (P < 0.05)