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. 2013 Aug 29;4(10):1673–1685. doi: 10.18632/oncotarget.1237

Figure 1. Transcriptional status of SIRT1 and H2AFZ in clinical samples (normal prostate tissues – NPT –, prostatic intraepithelial neoplasia – PIN – and prostate carcinoma - PCa) and PCa cell lines (LNCaP, DU145 and PC-3).

Figure 1

(A) SIRT1 downregulation and H2AFZ overexpression are early events in prostatic carcinogenesis (group analysis with Kruskal-Wallis test followed by a pairwise Mann-Whitney U test, **p<0.01, ***p<0.001 and ****p<0.0001); (B) SIRT1 and H2AFZ gene expression in PCa cell lines follow the tendency observed for clinical samples of prostatic malignancy (mean ± SD, n=3).