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. 2013 Aug 29;4(10):1673–1685. doi: 10.18632/oncotarget.1237

Figure 4. Epigenetic modulating drugs have the capacity to upregulate protein levels of sirtuin 1 and decrease levels of H2A.Z and c-Myc.

Figure 4

(A) Western blot analysis of sirtuin 1, H2A.Z and c-Myc of three PCa cell lines exposed to 5-aza-dC and/or TSA. Optical densities of visible bands for (B1) sirtuin 1, (B2) H2A.Z and (B3) c-Myc following treatment with 5-aza-dC and/or TSA. Intensity of the bands was normalized to the loading control β-actin and presented as folding variation in comparison to the untreated control (mean ± SD, n=3). Dunnet's test: *p<0.05, **p<0.01, ***p<0.001.