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. 2013 Oct 2;4(10):1829–1835. doi: 10.18632/oncotarget.1397

Figure 3. Anti-cancer activity of p62 vaccine in mouse solid tumors.

Figure 3

A. Dose-effect of p62 on LLC. Mice were treated with p62-encoding plasmid (pCL2) 14 and 7 days prior to tumor inoculation, and then at days 1, 8 and 15 after the inoculation. Tumor volumes were monitored by caliper starting from day 10 after tumor inoculation. The effect is observed with p < 0.05 for doses more than 90 μg/mouse.B. P62 vaccine suppresses growth of B16 melanoma. Mice received injections of p62-encoding plasmid on days 1, 8 and 14 after tumor inoculation. Growth of tumors was monitored by caliper starting from day 15. The effect is observed with p < 0.05. C. P62 vaccine suppresses growth of S37 sarcoma. Mice were injected with p62-encoding plasmid 14 and 7 days prior to tumor inoculation, and then at days 1, 8, 15, 22 and 29 after the inoculation. Tumor growth was monitored by caliper starting from day 9. The effect is observed with p < 0.05 starting on day 15th.