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. 2013 Nov 20;9(10):1079–1088. doi: 10.7150/ijbs.7595

Figure 2.

Figure 2

Histamine-induced membrane depolarization and inward currents in myelinated A-type vagal ganglion neurons (VGNs) isolated from adult male (black) and female (red) rats. A: representative action potentials (AP) elicited from A-types by a brief pulse; B: 1.0 μM histamine-induced membrane depolarization from resting membrane potential (RMP) near -60 mV observed on the same neurons shown in (A) using the gap-free protocol under current-clamp mode; C: 1.0 μM histamine-induced inward currents using the gap-free protocol with holding potential at -60 mV under voltage-clamp mode; (▲) represents the starting points of bath-perfusion of histamine. Horizontal scale bar shown in (C) also applies to (B).