Table 1.
Most differentially-expressed genes in GEN-treated hBMSCs as compared with control samples. Expression changes are expressed as a ratio of relative expression in GEN (+)/GEN (-) in the form of mean±SD. Genes are ordered by the ratio.
| GenBank | Description | Gene Name | Ratio(GEN+/GEN-) |
|---|---|---|---|
| Up-regulated genes(>2 fold) | |||
| NM_005247 | Fibroblast growth factor 3 | FGF3 | 12.028±4.223 |
| NM_001718 | Bone morphogenetic protein 6 | BMP6 | 6.234±0.306 |
| NM_001200 | Bone morphogenetic protein 2 | BMP2 | 5.954±0.506 |
| NM_001719 | Bone morphogenetic protein 7 | BMP7 | 4.913±1.545 |
| NM_001855 | Collagen, type XV, alpha 1 | COL15A1 | 4.720±0.436 |
| NM_005900 | MAD, mothers against decapentaplegic homolog 1 | SMAD1 | 4.427±1.273 |
| NM_000759 | Colony stimulating factor 3 | CSF-3 | 4.366±2.294 |
| NM_001844 | Collagen, type II, alpha 1 | COL2A1 | 3.827±0.358 |
| NM_000711 | Bone gamma-carboxyglutamate (gla) protein | OSTEOCALCIN | 3.782±0.692 |
| NM_000758 | Colony stimulating factor 2 | CSF-2 | 3.390±0.439 |
| NM_001202 | Bone morphogenetic protein 4 | BMP4 | 3.352±1.234 |
| NM_004348 | Runt-related transcription factor 2 | RUNX2/CBFA1 | 3.301±0.202 |
| NM_000604 | Fibroblast growth factor receptor 1 | FGFR1 | 3.152±0.285 |
| NM_001856 | Collagen, type XVI, alpha 1 | COL16A1 | 3.081±0.911 |
| NM_000088 | Collagen, type I, alpha 1 | COL1A1 | 2.711±0.522 |
| XM_044622 | Collagen, type XIV, alpha 1 | COL14A1 | 2.675±0.485 |
| NM_001201 | Bone morphogenetic protein 3 | BMP3 | 2.595±0.223 |
| NM_005903 | MAD, mothers against decapentaplegic homolog 5 | SMAD5 | 2.435±0.429 |
| NM_021073 | Bone morphogenetic protein 5 | BMP5 | 2.434±0.380 |
| NM_006128 | Bone morphogenetic protein 1 | BMP1 | 2.293±0.213 |
| NM_000800 | Fibroblast growth factor 1 | FGF1 | 2.169±0.160 |
| NM_000478 | Alkaline phosphatase | ALP | 2.168±0.136 |
| Down-regulate genes(<1/3 fold) | |||
| NM_002026 | Fibronectin-1 | FN1 | 0.607±0.076 |
| NM_002449 | Msh homeo box homolog 2 | MSX2 | 0.596±0.081 |
| NM_000093 | Collagen, type V, alpha 1 | COL5A1 | 0.569±0.050 |
| NM_005904 | MAD, mothers against decapentaplegic homolog 7 | SMAD7 | 0.490±0.122 |
| NM_005585 | MAD, mothers against decapentaplegic homolog 6 | SMAD6 | 0.432±0.096 |
| NM_001711 | Biglycan | BGN | 0.261±0.070 |
| NM_000612 | Insulin-like growth factor 2 (somatomedin A) | IGF-II | 0.225±0.053 |