Figure 3.

NR2B blockade during remote extinction leads to increased pCREB. A, After 3 d of extinction training, we found robust immunostaining for NR2B and pCREB, but not pERK, in RSC. pERK was highly expressed in ACC in the same brain. Arrowheads point to regions of dense immunostaining. Scale bar, 250 μm. B, Consistent with our previous results, infusion of Ro into RSC blocked remote fear extinction. Ro also led to an increase in pCREB+ cells relative to vehicle controls. Arrows indicate post-extinction infusions; *p < 0.05.