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PGRN deficiency increases BBB permeability to PDGF-CC. A, No major differences were observed in the mRNA expression of factors involved in vascular development and stability, except for PDGFRα (n = 6 per group; *p < 0.05, t test). B, After injection of PDGF-CC, EB leakage/BBB permeability is enhanced in PGRN+/− and KO (−/−) mice compared with WT (+/+) (n = 6–7 per group; *p < 0.05 from WT, ANOVA). Scale bar, 500 μm. AQP4, Aquaporin-4.
