Figure 10.

Changes in FGF8, Bmp, Nog expression and neuronal formation in the OP of control and mutant animals. A, C, Summary schematics. Bmp4 expression defines (arrow) expression of Nog; in Fgf8 hypomorphs (C), changes in Bmp4 expression in the ventromedial developing mesenchyme, secondary to FGF8 changes, alter Nog expression (red) and therefore the neurogenic potential of progenitors in the OP (green). B, D, Scatter plots showing mesenchymal Nog expression (orange/red/brown) and HuC/D-positive neurons (shades of green) in serial coronal sections of controls (n = 3) and Fgf8 hypomorphs (n = 3) embryos at E11.5. Each data series represents cells plotted on three serial section/embryo. In the Fgf8 mutant, the ventromedial source of Nog was dorsalized and correlated with changes in neurogenesis.