Figure 3.

Absence of training-induced occlusion of cLTP in the M1 of the fmr1 KO mouse. A, Average time course of the change in FPs after cLTP. Representative FPs (average of 5 traces) with the black and gray traces taken before (1) and after (2) cLTP, respectively (time points indicated on the graph). In the WT mice, cLTP is occluded in the trained hemisphere (black, n = 5 slices) compared with the untrained hemisphere (gray). In the fmr1 KO mice, no occlusion of cLTP is detected in the trained hemisphere (dark blue, n = 6 slices) compared with the untrained hemisphere (light blue). Scale bars: 0.4 mV, 5 ms. B, Average FPs 30–40 min after initiation of cLTP induction. Mean ± SEM. The interaction between genotype and training on cLTP was significant (p = 0.022, two-way ANOVA); *p < 0.05, **p < 0.01.