Figure 3.

Consolidation of vestibulo-cerebellar learning is impaired in Ts65Dn mice, but not rescued by SAG treatment. A, Polar plot showing the trajectory of VOR gain and phase change during adaptation for the different groups. Gain is represented as distance from the center and phase as the angle relative to perfect compensation at 0 degrees. Note the significant difference between the learning extent of EuVeh and both Ts65Dn groups. B, Schematic explanation of the consolidation calculation, exemplified with the EuVeh dataset. Consolidation of VOR adaptation is calculated by dividing the extent of the real learning vector (rExt) achieved after the 5-day training paradigm by the sum of the short-term learning vectors achieved each day as if there was no loss of learning overnight (sExt). Therefore, the rExt can be interpreted as the fraction of the short-term learning vectors retained between training days (dExt). C, Motor memory consolidation in the phase reversal task is significantly decreased in both TsVeh and TsSAG groups compared with EuVeh mice. Error bars represent SEM. Asterisks represent p < 0.05 after multivariate Hotteling's T² test (A) and Tukey–Kramer post hoc test (C).