Figure 3.

Ethanol increases mIPSC frequency. (A) Whole-cell voltage clamp electrophysiology recordings demonstrate that ethanol increases the probability of GABA release. The representative current traces in the upper panel were recorded in neurons exposed to 60 mM ethanol for 4–8 h (E) or a vehicle control (C). Magnified representative mIPSC events from control and ethanol-treated neurons are shown in the lower panel. (B) Ethanol increases the mean frequency of mIPSCs in neurons treated with ethanol (E) compared to vehicle control [C; n_C = 19, n_E = 22; t₍₃₉₎ = 2.51; p < 0.05]. (C) Ethanol does not alter the mean amplitude of mIPSCs in neurons exposed to ethanol (E) or vehicle control [C; n_C = 19, n_E = 22; t₍₃₉₎ = 0.24; p = 0.81; ^*P < 0.05].