Table 1.
Mouse models of oxytocin system function.
| Gene | Mouse name | Description of manipulation | Original reference |
|---|---|---|---|
| Oxt | OXT KO (OT KO); Oxttm1Zuk | Congenital knockout on mixed 129/B6; *also available on C57Bl/6j | Nishimori et al., 1996; *Hammock and Levitt, unpublished |
| Oxt | OXT KO; Oxttm1Wsy | Congenital knockout on mixed 129/B6 | Young et al., 1996b |
| Oxt | Oxt/EGFP | EGFP labeled OXT-neurophysin pre-prohormone; backcrossed for many generations to C57BL/6 | Zhang et al., 2002 |
| Oxtr | OXTR KO; Oxtrtm1.1Knis | Congenital knockout on mixed 129/B6; *also available on C57Bl/6j | Takayanagi et al., 2005; *This report |
| Oxtr | Oxtrtm1(KOMP)Vlcg | Congenital knockout on C57BL/6 | Velocigene; www.komp.org |
| Oxtr | Oxtrflox; Oxtrtm1.1Wsy | Floxed OXTR for use with Cre recombinase for selective excision | Lee et al., 2008a |
| Oxtr | Oxtr-Venus | Venus reporter in place of Oxtr; reporter positive mice are Oxtr hemizygous or KO; on mixed 129/B6 | Yoshida et al., 2009 |
| Oxtr | Oxtr-EGFP; Tg(Oxtr-EGFP)GO185Gsat | BAC transgenic with OXTR promoter driven expression of EGFP; theoretically does not interfere with native OXTR | GENSAT, 2003; Gong et al., 2003 |
| Oxtr | OXTR-cre; Tg(Oxtr-cre)ON66Gsat | Cre recombinase driven by the OXTR promoter | GENSAT, 2003 |
| Oxtr | tetOXTR | Tetracycline responsive OXTR promoter for selective regional and/or temporal over-expression; backcrossed to C57Bl/6j | L. J. Muglia pers. comm |
| Oxtr | OTR-LacZ | Oxtr promoter drives LacZ expression; LacZ allele results in lower Oxtr expression; on 129 × Balb/c mixed background | Gould and Zingg, 2003 |
| CD38 | CD38-/- | Congenital loss of CD38 which regulates secretion of OXT; On ICR x B6 X DBA | Kato et al., 1999; Jin et al., 2007 |