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. 2013 Dec 11;4:355. doi: 10.3389/fphys.2013.00355

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Copyright © 2013 Tewari, Bugenhagen, Wang, Schreier, Carlson, Chesler and Beard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Pulmonary vascular resistance (R_PVB), (B) Pulmonary artery elastance (E_PA), and (C) unloaded pulmonary artery volume (Vd_PA) as a function of increasing days of hypoxia and treatment with SUGEN. The closed circles represent mean (with standard error) taken over 0-day (n = 4), 14-day (n = 6), 21-day (n = 8), and 28-day (n = 7) hypoxic mice group. The decrease in Vd_PA and increase in E_PA is statistically significant only for the 28-day group (p < 0.001).