Table 2.

Parameters estimated to represent HySu dependent changes in model.

Parameter	0-day (n = 4)	14-day (n = 6)	21-day (n = 8)	28-day (n = 7)
TriSeg PARAMETERS
ALWm, ref	0.59±0.07	0.59±0.09	0.60±0.06	0.61±0.08
ASWm, ref	0.10±0.01	0.12±0.02	0.11±0.01	0.11±0.01
ARWm, ref	0.50±0.01	0.57±0.04*	0.59±0.05*	0.60±0.03*
vmax	12.36±0.8	14.4±4.2	14.1±3.1	15.2±3.8
CIRCULATORY PARAMETERS
RPVB	154.32±11.1	286.52±57.2*	265.5±43.4*	356.6±37.6*
EPA	437.78±26.6	560.3±101.7	622.5±172.1	938.6±161.6*
VdPA	0.16±0.01	0.12±0.028	0.121±0.031	0.048±0.03*
R†ABC	1442.6±86.2	1946±394.3	1769.2±271.1	1883.3±453.2
RPBC†	569.6±32.9	804.3±121.9*	644.3±63.5	741±61.8*
EVC	103.8±6.6	103.8±25.3	123.0±45.5	69.8±16.2*
VdVC	0.45±0.04	0.40±0.07	0.43±0.03	0.49±0.05
pVCO	88.6±1.4	81.21±0.07	80.8±0.04*	89.6±0.03

^†These resistances were increased from their baseline values (shown in Table 1) to account for blood hematocrit increase in hypoxic mice.

^*Indicates rejection of null-hypothesis at 5% significance level using two-tailed student's t-test with p <0.05 vs. 0-day hypoxic mice.