Table 3.

Cognitive Function at Each Cognitive Assessment, by Multivitamin Status

Cognitive Test	Treatment Assignment				Difference in Score, Mean (95% CI)‡, Multivitamin – Placebo
	Multivitamin Group		Placebo Group
	No. of Subjects	Mean (SE)†	No. of Subjects	Mean (SE)
Global score*
1	2978	0.01 (0.01)	2964	−0.00 (0.01)	0.01 (−0.02, 0.05)
2	2657	0.02 (0.01)	2639	0.01 (0.01)	−0.01 (−0.05, 0.03)
3	2091	−0.13 (0.02)	2015	−0.15 (0.02)	0.02 (−0.03, 0.06)
4	1165	−0.26 (0.02)	1159	−0.28 (0.02)	0.02 (−0.04, 0.08)
Verbal memory scorea
1	2978	0.00 (0.01)	2964	−0.00 (0.01)	0.01(−0.03, 0.05)
2	2657	0.03 (0.01)	2639	0.03 (0.02)	−0.00 (−0.05, 0.04)
3	2091	−0.08 (0.02)	2015	−0.10 (0.02)	0.02 (−0.03, 0.07)
4	1165	−0.16 (0.02)	1159	−0.18 (0.02)	0.01 (−0.05, 0.07)
TICS score
1	2980	34.3 (0.05)	2967	34.3 (0.05)	0.04 (−0.09, 0.18)
2	2657	34.5 (0.05)	2639	34.5 (0.06)	0.10 (−0.05, 0.24)
3	2091	34.0 (0.07)	2015	34.0 (0.07)	0.00 (−0.18, 0.19)
4	1165	33.2 (0.09)	1159	33.1 (0.09)	0.12 (−0.14, 0.38)
Category fluency score
1	2978	20.1 (0.11)	2964	20.0 (0.11)	0.02 (−0.29, 0.33)
2	2657	20.0 (0.11)	2639	20.2 (0.12)	−0.21 (−0.53, 0.12)
3	2091	18.8 (0.12)	2015	18.7 (0.13)	0.04 (−0.31, 0.40)
4	1165	18.5 (0.15)	1159	18.3 (0.15)	0.22 (−0.21, 0.65)

Abbreviations: CI, confidence interval; TICS, Telephone Interview of Cognitive Status.

^*Global score is a composite of TICS, immediate and delayed recalls of the East Boston Memory Test, category fluency, and delayed recall of the TICS 10-word list. Verbal memory score is a composite score of the immediate and delayed recalls of both the TICS 10-word list and the East Boston Memory Test.

^†Least squares mean and standard errors.

^‡Differences from longitudinal models of mean cognitive performance.