Table 4.

Mean Differences in Cognitive Decline Between Multivitamin and Placebo Groups, from Initial Assessment

Cognitive Test	Difference in cognitive decline^†, Mean (95% CI) Multivitamin group – Placebo group	p- value
Global score^*
From initial cognitive assessment to
2^nd cognitive assessment	−0.02 (−0.05, 0.02)	0.28
3^rd cognitive assessment	0.01 (−0.04, 0.05)	0.79
4^th cognitive assessment	0.01 (−0.05, 0.06)	0.77
Average over follow-up	−0.01 (−0.04, 0.02)	0.53
Verbal memory score^a
From initial cognitive assessment to
2^nd cognitive assessment	−0.02 (−0.06, 0.02)	0.43
3^rd cognitive assessment	0.01 (−0.03, 0.06)	0.57
4^th cognitive assessment	0.01 (−0.05, 0.07)	0.84
Average over follow-up	−0.005 (−0.04, 0.03)	0.80
TICS score
From initial cognitive assessment to
2^nd cognitive assessment	0.04 (−0.10, 0.18)	0.59
3^rd cognitive assessment	−0.04 (−0.21, 0.13)	0.64
4^th cognitive assessment	0.07 (−0.18, 0.32)	0.59
Average over follow-up	0.02 (−0.11, 0.15)	0.79
Category fluency score
From initial cognitive assessment to
2^nd cognitive assessment	−0.22 (−0.52, 0.09)	0.165
3^rd cognitive assessment	0.05 (−0.30, 0.40)	0.77
4^th cognitive assessment	0.22 (0.21, 0.65)	0.31
Average over follow-up	−0.07 (−0.35, 0.20)	0.59

Abbreviations: CI, confidence interval; TICS, Telephone Interview of Cognitive Status

Global score is a composite of TICS, immediate and delayed recalls of the East Boston Memory Test, category fluency, and delayed recall of the TICS 10-word list. Verbal memory score is a composite score of the immediate and delayed recalls of both the TICS 10-word list and the East Boston Memory Test.

^†

From longitudinal models of least-squares means of change in cognitive performance from the initial assessment, and averaged over follow-up. The number of subjects in each assessment is shown in Table 3.